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Some patients have reported complete relief of symptoms after discontinuing the bisphosphonate, whereas others have reported slow or incomplete resolution.

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Severely suppressed bone turnover: a potential complication of alendronate therapy.

Assessment of iron studies is helpful in the patient who presents with non-specific symptoms of lethargy, even in the absence of anaemia.

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Long-term antibiotic therapy and surgery to remove dying bone tissue may be required.

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In our study, annual infusions of zoledronic acid (5 mg) for 3 years were evaluated to determine whether they reduced the risk of vertebral, hip, and other types of fracture.

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In this trial, patients received supplemental daily doses of elemental calcium (1000 to 1500 mg) and vitamin D (400 to 1200 IU).

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It's not as standardly used with second or third line therapies, but it's certainly feasible to combine Avastin with the other agents noted above.

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Comparison: The two treatments have not been tested head-to-head, so we have no idea of their comparative effectiveness, but we know of some differences between the two products.

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Mice are protected from lytic bone lesions using bisphosphonates and osteoprotegerin (m OPG).

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Other conditions where infusion therapy may be helpful include acute attacks of vertigo and others where dizziness and or nausea are prominent symptoms.

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Currently FDA-approved bisphosphonates, including Fosamax (alendronate), Actonel (risedronate), Didronel (etidronate), Boniva (ibandronate), and Reclast (Zometa) (zoledronate), are designed to strengthen bone by inhibiting normal osteoclastic bone resorbing activity, which slows the loss of bone mineral density (BMD), allowing the trabecular architecture to stabilize.

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Single and multiple infusions in patients with both normal and impaired renal function have been associated with renal deterioration, resulting in renal failure and dialysis (rare).

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Zolendronate strengthens bone and is primarily used to treat osteoporosis.

Researchers found that postmenopausal women experienced significant amounts of bone growth by taking a bone-building drug called teriparatide with denosumab, a targeted therapy drug used to stop bone loss.

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The Mayo Clinic also reports that the highest risk of bisphosphonate-linked jaw necrosis appears to be related to the use of intravenous zoledronic acid, sold under the names Zometa, Zomera, Aclasta and Reclast.

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This reduction was similar to that reported in postmenopausal women with osteoporosis who received zoledronic acid (relative reduction in the risk of vertebral fracture, 71% at 2 years), suggesting that the antifracture effect of zoledronic acid is independent of sex.

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Zoledronic Acid Injection is not indicated for use in children.

Some 60% of cases are preceded by a dental surgical procedure (that involve the bone), and it has been suggested that bisphosphonate treatment should be postponed until after any dental work to eliminate potential sites of infection (the use of antibiotics may otherwise be indicated prior to any surgery).

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