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Rehabilitation approaches mostly focus on inhibiting or modulating the spasticity and include prolonged stretching and ROM exercises, inhibitory strategies such as casting or splinting, and the use of electrical stimulation such as subthreshold sensory stimulation and transcutaneous nerve stimulation (TENS).

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Participants on anti-spasticity medications and those who were not taking these medications experienced similar reductions in spasticity.

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Studies investigating the long-term effects of baclofen in large cohorts of patients should help to characterize some of the factors affecting the efficacy of baclofen.

Drugs such as carbamazepine have effects on neural tissue that are somewhat similar to those of the antiarrythmics; they selectively inhibit neural activity.

Noting that anxiety is a common symptom in patients being treated for alcohol withdrawal and alcohol dependence, activating GABA B receptors might be useful in the treatment of alcohol withdrawal and dependence.

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