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Green stool is also common, especially after eating green or purple foods, However, green stool that continues for a longer time could actually be because of a medical problem.

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When prostate cancer has spread to nearby tissues or metastasized to other areas in the body, treatment measures include androgen-deprivation therapy, chemotherapy, and biologic therapy.

CONTACT YOUR DOCTOR IMMEDIATELY if you experience black or bloody stools; blurred vision or other vision changes; bone pain; breast growth or pain; changes in the amount of urine produced; chest pain; dark or bloody urine; fainting; fever, chills, or persistent sore throat; flu-like symptoms; increased hunger, thirst, or urination; joint pain, stiffness, or swelling; loss of appetite; mental or mood changes (eg, anxiety, depression); muscle aches or weakness; numbness or tingling of the skin; pale stools; severe or persistent cough; severe or persistent dizziness, drowsiness, or headache; severe or persistent nausea or stomach pain; shortness of breath; swelling of the ankles, legs, or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; weight change; or yellowing of the skin or eyes.

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In some cases, gynecomastia may be disturbing enough to cause men to discontinue therapy.

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Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J; Drug Induced Liver Injury Network (DILIN).

The Panel did not include the other treatment options in the analysis and recommendations due to a combination of factors, including limited published experience and short-term follow-up as well as the similar issues that affected evaluations of other treatment options (see the "Methodology" and the "Summary of Treatment Complications" sections for an explanation of data limitations).

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Ketoconazole reduces androgen production in the testes and the adrenal glands.

In vitro studies have shown that R-bicalutamide is an inhibitor of CYP 3A4 with lesser inhibitory effects on CYP 2C9, 2C19 and 2D6 activity.

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Firstly the number of experimental and clinical studies remains relatively small and secondly they are often limited in terms of their quality (lack of adequate numbers to achieve statistical significance, lack of randomized controlled trials, and the findings that these compounds only appear to have marginal efficacy when assessed in head-to-head clinical trials).

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