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Refer to the "Immunization" section of this chapter in the original guideline document for comprehensive information on immunizations.

How Is Polycythemia Vera Treated?

It can cause very low blood counts, but in terms of actually damaging the cells to cause by itself most people do not feel this is the case.

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Postdischarge pain, functional limitations and impact on caregivers of children with sickle cell disease treated for painful events.

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HYDREA may cause temporary impairment of renal tubular function accompanied by elevations in serum uric acid, blood urea nitrogen (BUN), and creatinine levels.

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JAK2 in myeloproliferative disorders.

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At study exit, subjects randomized to placebo still exhibited laboratory effects of alpha thalassemia and other modifiers, while those assigned hydroxyurea had treatment effects that exceeded most genetic influences.

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Coagulopathy as assessed by the PT test is often found.

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Hydroxyurea blocks an enzyme produced by human cells.

Importance of informing patients of the increased risk of a secondary malignancy associated with use of the drug.

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They scored considerably worse than the reference group with the lowest SF-36 scores, namely patients with myocardial infarction, and also worse than the reference group with chronic pain, namely arthritis.

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The Baby Hug Trial demonstrated that like adults, children taking hydroxyurea regularly also had fewer episodes of pain, hospitalizations, and blood transfusions than children who did not take hydroxyurea.

Because hydroxyurea is very inexpensive compared with most drug treatments, and generic forms of hydroxyurea have documented efficacy, treatment should be strongly considered for children in developing countries.

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Pulmonary artery thrombosis during acute chest syndrome in sickle cell disease.

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The red blood cell count drops, which results in anemia.

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH).

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As hematologists, we owe our patients with SCA the opportunity to enjoy healthy and productive lives with good quality.

An antagonist at the opioid mu receptors, it is useful for moderate-to-severe pain in sickle cell disease.

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Management of sickle cell disease.

It also causes smooth muscles to contract, gastric acid to be made, and the heart rate to increase.

Table 1 Laboratory Values before and after Treatment with Hydroxyurea.

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