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I have been taking methotrexate for about 2 years for my rheumatoid arthritis. The medication helps me to decrease pain significantly and it does control inflammation. Some time ago I stopped taking it for 2 months because I would be able to go on without it, but my symptoms returned so I started taking it again. Great medication.
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Anemia (caused by folate deficiency)Folate deficiency may cause megaloblastic anemia, a blood disorder in which there are very large red blood cells.
Some investigators suggest that the future of treatment and understanding of RA may be based on imprinting and epigenetics.
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Among 4 patients with psoriasis on methotrexate for more than 10 years using daily regimens, 2 had cirrhosis, but 2 had no fibrosis on biopsy).
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Areas under the curve for nearly all clinical variables were significantly lower-that is, there was a better clinical effect for the intensive treatment group compared with the conventional treatment group.
Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.
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Genetic factors may play some role in RA either in terms of increasing susceptibility to developing the condition or by worsening the disease process.
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Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis".
Discuss potential drug interactions, especially salicylates and over-the-counter NSAIDs.
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With high dose intravenous methotrexate, serum ALT levels can rise to 10 to 20 times the upper limit of normal (ULN) within 12 to 48 hours, but levels then fall rapidly to normal with only rare instances of jaundice or symptoms of liver injury.
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But that said, biologics should only be used if conventional DMARDs do not work well enough for you on their own.
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Usually, reducing or stopping methotrexate will allow the liver to return to normal function levels.
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Methotrexate appears to work better than smokers, and those who start on Methotrexate in the earliest stages of psoriasis and rheumatoid arthritis tend to find that the drug works better as well.
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BACKGROUND: Methotrexate is an antimetabolite used in the treatment of neoplastic diseases, severe psoriasis, and rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis.
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Two reports describe in vitro methotrexate inhibition of DNA precursor uptake by stimulated mononuclear cells, and another describes, in animal polyarthritis partial correction by methotrexate of spleen cell hyporesponsiveness and suppressed IL 2 production.
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Results from a single-blind, randomized controlled trial initially suggested that this combination was no better than monotherapy using either drug.
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