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I have been taking Mirapex for a number of years for RLS. I originally took 0.125mg once a day. After a few years it was increased to 0.125mg twice a day as my symptoms were rather severe. I have remained at the same dosage since then and have developed no side effects to the medication. I would seldom be able to sleep except for this medication.
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I had suffered restless legs syndrome periodically for many years. Then, suddenly, I was getting RLS every night. The weird thing, to me, is that I also had the feelings in my arms, but certainly not as frequently as the legs. After weeks of trying to reposition my legs, ignoring it (impossible!), I finally went to my doctor. I took my first dose that night, and haven't had symptoms ever since. I read up on the long-term usage, and am a little concerned about it. I'll cross that bridge if and when I cross it.

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One of the most important things to remember about diagnosing PD is that there must be two of the four main symptoms present over a period of time for a neurologist to consider a PD diagnosis.

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It immediately helped my RLS.

Many studies report that augmentation (worsening of symptoms that occur earlier in the day) occurs in up to 70% of patients who take L-dopa.

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Sleepiness caused by pramipexole dihydrochloride tablets can happen as late as one year after you start your treatment.

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For tremor, he used hyoscyamine and also noted arsenic, morphia, conium (hemlock), and “Indian hemp” ( cannabis) as effective agents for temporary tremor abatement.

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