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The DFCI ALL Consortium reported that a study of 51 adolescents aged 15 to 18 years in a pediatric trial had a 5-year EFS of 78%.
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Evaluate the activity of imatinib mesylate and hydroxyurea, as measured by 6-month progression-free survival, in patients with recurrent or progressive meningioma.
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Evaluation of the safety and efficacy of an oral molecularly-targeted therapy, STI-571, in patients (pts) with unresectable or metastatic gastrointestinal stromal tumors (GISTS) expressing C-KIT.
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However, in a review of a large number of patients treated on Children's Oncology Group (COG) trials over a 15-year period, T-cell immunophenotype still proved to be a negative prognostic factor on multivariate analysis.
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We are indebted to the coinvestigators; to the members of the medical, nursing, and research staff at trial centers; to Sofia Fernandes Reese; to the clinical-trial monitors and the data managers and programmers at Novartis for their contributions; and to Iris Van Hoomissen, Elisabeth Wehrle, Monique Ben-Am, Marianne Rosamilia, Charlene So, Carsten Goessl, and Martee Hensley for their invaluable collaboration.
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Identify HIV associated immune complex diseases (HIVICDs) with its relatively good prognosis as distinct from the classic HIV associated nephropathy (HIVAN).
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At the time of study closure, 61% and 63% of dasatinib- and imatinib-treated patients remained on initial therapy, respectively.
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KIT or PDGFRA mutation was detected in 333 of 366 tumors (91%) available for testing.
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GIST with exon 18 mutations is most frequent in these cases (80%) and point mutations that produce D842V is known to be associated with resistance to imatinib.
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The preclinical development of the BCR-ABL kinase inhibitor, imatinib and highly successful clinical trials of this agent for patients with CML will be reviewed along with the most up-to-date follow-up on these studies.
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In addition to treating blood cancers, imatinib has also proved effective against gastrointestinal stromal tumor (GIST), a rare cancer of the digestive tract, by blocking a mutated protein called KIT.
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The percentage of lysis of PKI-treated cells compared to the controls was then calculated by dividing lysis of Imatinib-, Nilotinib- or Dasatinib-treated cells by lysis of control cells.
The purpose of this study is to find the highest dose of SAR405838 that can be given safely in patients with liposarcoma and other advanced cancers that have either continued to grow despite standard therapy or for which no standard treatments exist.
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While the median survival used to be 4 to 6 years, with the advent of the new oral therapies, the median survival is expected to approach normal life expectancy for most patients, although it is still too soon to say this definitively.
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