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Episodes of hepatitis were considered drug induced if transaminases were normal before therapy, increased during therapy, and returned to normal after discontinuation of the responsible drug.
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To give LTBI treatment to someone with active TB is a serious error: the TB will not be adequately treated and there is a risk of developing drug-resistant strains of TB.
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The bacteria are put into the air when a person with active TB disease of the lungs or throat coughs or sneezes.
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Three patients experienced suicide-related adverse reactions (one completed suicide and two suicide attempts) while receiving Daliresp compared to one patient (suicidal ideation) who received placebo.
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Some of the chronic presentations of the infection may resemble other diverse disorders, and diagnosis of TB with such an invidious presentation of deeper tissue infection is extremely difficult.
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Refsum's disease, G6PD deficiency, xanthomas, gout and porphyria), nutritional deficiency disorders (kwashiorkar, marasmus, phrynoderma, pellagra, scurvy, acrodermatitis enteropathica, carotenemia and lycopenemia) and miscellaneous disorders such as vitiligo, aphthous ulcers, cutaneous vasculitis and telogen effluvium.
For the first 2 months you are advised to take rifampicin, isoniazid, ethambutol and pyrazinamide for normal resistance free tuberculosis.
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Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use.
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Testing of multiple specimens per patient had a modest effect over the yield of a single assay performed directly on sputum.
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Therefore, analysis of gene mutations associated with resistance to anti-tuberculosis drugs and assessment of the performance of molecular methods for drug resistance testing in different settings are needed to ensure acceptable performance of the assays.
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As with hospitals, academic institutions can provide benefits to other participants in TB control.
Together with INH, RIF is a major frontline anti-TB agent and has been included in standard chemotherapy since the 1980s.
The third group that requires BCG vaccination are those at high-risk occupations that includes people under 35 years of age whose occupation expose them to tuberculosis infected persons.
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Recognition of these shortcomings in PT monitoring stimulated the development of the INR standard for monitoring oral anticoagulant therapy, and the adoption of this standard improved the safety of oral anticoagulant therapy and its ease of monitoring.
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In a hypothetical cohort, where the prevalence of rifampicin resistance is 2%, the number of individuals wrongly identified as rifampicin resistant would increase from 14 (when rifampicin resistance prevalence is 30%) to 20, an increase of 43%.
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Each laboratory considering starting a testing program should perform a cost-benefit analysis to determine the amount of testing that can be done without adversely affecting other laboratory functions.
Greeks did not apply to this disease the term lepra (“scaly”), from which the modern term leprosy is derived; instead, they referred to it as elephantiasis græcorum.
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Each of these potential TB drugs is currently undergoing evaluation in a phase 3 trial, to see how effective it is when substituted for either ethambutol or isoniazid, to shorten the treatment of drug sensitive TB from the standard six months to four months.
Treatment for MDR-TB must be given for a minimum of 18 months and cannot be stopped until the patient has been culture-negative for a minimum of nine months.
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Particular attention was paid to liver function considering reports of jaundice in pregnancy, oral contraception, and use of rifampicin with isoniazide.
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